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Larry Lucchino, who as a top executive with the Baltimore Orioles and San Diego Padres oversaw the design of modern stadiums that evoke their surroundings — Oriole Park at Camden Yards in Baltimore and Petco Park in San Diego — and who as president of the Boston Red Sox helped to preserve Fenway Park for generations, died on Tuesday at his home in Brookline, Mass. He was 78.

His family announced the death but did not give a cause. He had been treated for cancer three times.

Mr. Lucchino became president of the Red Sox in 2002 with the ascension of new ownership, led by John Henry, the principal owner of the Red Sox, and Tom Werner. In Mr. Lucchino’s 14 years with the team, the Red Sox won three World Series titles — the first of which, in 2004, broke an 86-year drought — and reached the postseason seven times. He oversaw improvements to Fenway Park that included installing seats above the Green Monster, the 37-foot-high left field wall, expanding crowded concourses and creating new concession areas.

Rather than replacing it with a new stadium, Mr. Lucchino envisioned a renovation that would keep Fenway, which opened in 1912, viable for decades.

“Have you learned nothing?” Mr. Lucchino said to Charles Steinberg, another Red Sox executive, as quoted in a profile in The Sports Business Journal in 2021. “You can’t destroy the Mona Lisa. You preserve the Mona Lisa.”