Colts vs. Steelers odds, spread, line: Monday Night Football picks, NFL predictions from top model

The Pittsburgh Steelers will try to post their second win in three weeks when they take on the Indianapolis Colts on Monday Night Football. The Steelers (3-7), who are coming off a 37-30 loss to the Cincinnati Bengals, defeated the New Orleans Saints 20-10 in Week 10. The Colts (4-6-1), who are 1-1 under interim coach Jeff Saturday, suffered a 17-16 loss to the Philadelphia Eagles last week. Indianapolis will be out to snap a seven-game skid against Pittsburgh.

Kickoff from Lucas Oil Stadium in Indianapolis is set for 8:15 p.m. ET. Indianapolis is a 2.5-point favorite in the latest Colts vs. Steelers odds from Caesars Sportsbook, while the over/under for total points scored is 39.5. Before locking in any Steelers vs. Colts picks or NFL bets, you have to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has broken down Colts vs. Steelers on MNF. You can head to SportsLine to see the picks. Here are the NFL lines and trends for Steelers vs. Colts:

• Colts vs. Steelers spread: Indianapolis -2.5
• Colts vs. Steelers over/under: 39.5 points
• Colts vs. Steelers money line: Steelers +118, Colts -140
• PIT: Steelers are 6-2 against the spread in their last eight games following an ATS loss
• IND: Colts are 7-3 ATS in their last 10 games following a straight-up loss
• Colts vs. Steelers: See picks at SportsLine

Why the Colts can cover

Wide receiver Parris Campbell is looking for his third game in a row with five or more catches and 65-plus receiving yards. He had five catches for 53 yards in the last meeting with the Steelers, a 28-24 loss at Pittsburgh on Dec. 27, 2020. For the season, Campbell has 44 receptions for 440 yards and three scores. He also has five big plays, including a long of 38 yards, and 23 first-down conversions.

Defensive end Yannick Ngakoue tied his season high with 1.5 sacks and had his first forced fumble of the season last week. He will be looking for his sixth game in a row with at least a half-sack. He has registered 21 tackles on the year, including 11 solo, with 6 1/2 sacks for 39 yards and four tackles for loss. In his eight-year career, Ngakoue has 62 sacks, 21 forced fumbles and three fumble recoveries. See which team to pick here.

Why the Steelers can cover

Tight end Pat Freiermuth tied his career-high with eight catches and had 79 receiving yards last week against the Bengals. He has 50-plus receiving yards in three of his past four games and is looking for his third road game in a row with 50 or more receiving yards. Freiermuth ranks third among AFC tight ends in catches (44) and receiving yards (482). He has at least two catches in the nine games he has played in.

Linebacker T.J. Watt had his sixth career interception last week and has two on the year in just three games played. Watt had two sacks and a forced fumble in the last meeting with the Colts and is aiming for his third game in a row against Indianapolis with 1.5 or more sacks. He has 12.5 sacks in 10 career Monday Night Football games. He will be looking for his third game in a row on Monday Night Football with three or more sacks and sixth in a row on MNF with a tackle for loss. See which team to pick here.

How to make Colts vs. Steelers picks

The model has broken down Monday Night Football's Steelers vs. Colts matchup from all angles. It is leaning Over the total, with the model projecting 41 combined points. It also says one side of the spread hits almost 60% of the time. See who it is at SportsLine.

So who wins Steelers vs. Colts on Monday Night Football And which side of the spread hits almost 60% of the time? Visit SportsLine now to find out which side of the Steelers vs. Colts spread you should be all over, all from the model on a 155-109 roll on its top-rated NFL picks, and find out.