Cowboys vs. 49ers prediction, odds, line, spread: Sunday Night ...

The Dallas Cowboys will try to get revenge on a San Francisco 49ers team that has ended their season the last two years when the two teams collide on Sunday Night Football. Two seasons ago in a wild card matchup, the 49ers jumped out to a 23-7 lead before holding on for a 23-17 victory. And then earlier this year in the divisional round, the 49ers made two key interceptions of Cowboys quarterback Dak Prescott in a 19-12 win. This season, both San Francisco (4-0) and Dallas (3-1) again are two of the favorites to represent the NFC in the Super Bowl. 

Kickoff is at 8:20 p.m. ET. San Francisco is a 3.5-point favorite in the latest Cowboys vs. 49ers odds, while the over/under for total points scored is 45. Before you make any 49ers vs. Cowboys picks or NFL predictions, you need to see the NFL betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2023 NFL season on an incredible 168-118 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 22-10 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has zeroed in on 49ers vs. Cowboys and locked in another confident against-the-spread pick. You can see the model's pick only at SportsLine. Now, here are several NFL odds and betting lines for Cowboys vs. 49ers:

• Cowboys vs. 49ers spread: San Francisco -3.5
• Cowboys vs. 49ers over/under: 45 points
• Cowboys vs. 49ers money line: San Francisco -186, Dallas +156
• SF: RB Christian McCaffrey leads the NFL in rushing yards (459)
• DAL: The defense leads the league in pressure rate (55%)
• Cowboys vs. 49ers picks: See picks here
• Cowboys vs. 49ers live stream: fubo (try for free)

Why the 49ers can cover

San Francisco has one of the top defenses in the league. The 49ers are giving up just 14.5 points per game, tied for third in the NFL. They also allow just 284.3 yards per game, which ranks fifth. The last time San Francisco met Dallas, in the divisional round of last season's playoffs, the 49ers held the Cowboys to just 12 points and 282 yards of total offense in a 19-12 win.

In addition, quarterback Brock Purdy continues to play effectively. Since he made his first career start in Week 14 of last season, he leads the league in touchdown-to-interception ratio (16-2) and passer rating (117.1). This season alone, he has a passer rating of 115.1, the best in the NFL. See which team to pick here.

Why the Cowboys can cover

Micah Parsons is arguably the best defensive player in the league. The versatile attack man leads the NFL in pressure rate (26%) this season (among 103 players with 75-plus pass rushes). Last week against New England, he had 10 pressures, which is tied for the most pressures by any player in a game this season.

Parsons spearheads a defense that has the ability to slow San Francisco running back Christian McCaffrey. Dallas is holding opposing running backs to 3.9 yards per carry this season, which is ninth-best in the NFL. Last Sunday against the Patriots, the Cowboys limited New England to just 53 rushing yards on 23 carries (2.3 yards per rush). See which team to pick here.

How to make 49ers vs. Cowboys picks

Now, the model has broken down Cowboys vs. 49ers from every angle. The model is leaning Under the point total, projecting the teams to combine for 43 points. It also says one side of the spread hits in almost 60% of simulations. You can see the model's NFL picks and analysis only at SportsLine. 

So who wins 49ers vs. Cowboys on Sunday Night Football, and which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the 49ers vs. Cowboys spread you should jump on, all from the advanced model that is up more than $7,000 on top-rated NFL picks, and find out.