Chiefs Defeat Chargers, 17-10, Behind a Stellar Defensive ...

Los Angeles then appeared poised to immediately answer, but the Chiefs' defense held on downs at the Kansas City 3-yard line, and two drives later, Perine had the Chiefs in front for the first time all day following a five-play, 60-yard scoring series.

"Everybody contributed there. We got a nice mix of the run and the pass [working] together," said Reid when asked about the go-ahead scoring drive. "We were getting positive yards on them, and once you get that [balance] going, you're [in good shape]."

Worthy hauled in Mahomes' third-down pass soon after the scoring drive, and despite a slew of mistakes early in the contest, Kansas City had itself a fourth-straight victory to begin the year.

"At the beginning of the game, in general, we were trying to do too much. We had the fumble and the interception, but I think guys stepped up [as the game went on]," Mahomes said. "At the end of the day, we got the win, and that's what's important."