Ohio State vs. Oregon odds, line: 2024 college football picks, Week ...

One of the most-anticipated matchup of the season takes place on Saturday when No. 2 Ohio State battles No. 3 Oregon. The Buckeyes are one of the most complete teams in college football, while the Ducks feature an experienced lineup that can compete with any team in the country. Ohio State is 10-1 in its last 11 matchups against Big Ten opponents, but Oregon is 11-0 in its last 11 games at home. The winner will be in prime position to make the College Football Playoff with both teams entering with undefeated records. Ohio State is 3-2 against the spread this season, while Oregon is 1-4 ATS. 

Kickoff from Autzen Stadium is set for 7:30 p.m. ET. After opening at -1.5, the Buckeyes are now favored by 3.5 points in the latest Ohio State vs. Oregon odds via SportsLine consensus, and the over/under is 54 points, down 2.5 points from the opening line. Before entering any Oregon vs. Ohio State picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread, and is 8-4 on top-rated picks over the past two weeks of this season. Anyone who has followed it has seen strong returns.

The model has set its sights on Ohio State vs. Oregon. You can head to SportsLine to see its picks. Here are several college football betting lines for the spread, money line and over/under:

• Oregon vs. Ohio State spread: Ohio State -3.5
• Oregon vs. Ohio State over/under: 54 points
• Oregon vs. Ohio State money line: Ohio State -161, Oregon +134
• Oregon vs. Ohio State picks: See picks here
• Oregon vs. Ohio State streaming: FuboTV (Try for free)

Why Ohio State can cover

The Buckeyes are giving up just 6.8 points per game on defense this season, the fewest in college football. Ohio State has held the opposition to seven points or less in four of its first five games, including last week's 35-7 win over Iowa. The Buckeyes held the Hawkeyes to just 110 yards passing in the victory.

Offensively, Ohio State is scoring 46.0 points per game, fourth-best in the nation. The Buckeyes are extremely effective on the ground, averaging 222.2 rushing yards per game. Quarterback Will Howard has also been playing well in his first season in the Big Ten. Howard completed 21 of 25 passes for 209 yards and four touchdowns against Iowa last week. For the season, Howard has completed 71.5% of his passes for 1,248 yards, 12 touchdowns and three interceptions. See which team to pick here. 

Why Oregon can cover

Quarterback Dillon Gabriel has been sensational in his first season with the Ducks. The senior signal caller has thrown for 1,449 yards, 11 touchdowns and three interceptions. He's thrown two or more touchdown passes in every game this season and he's recorded a rushing TD in three of his past four contests.

The Ducks also feature a plethora of weapons on the outside, including wide receiver Tez Johnson. Johnson has hauled in 43 receptions for 395 yards and five touchdowns, averaging 9.2 yards per catch. Over his last three games, the senior has recorded 18 catches for 315 yards and three scores. Running back Jordan James is also effective for Oregon's offense, rushing for 552 yards and five touchdowns on 88 carries. See which team to pick here. 

How to make Oregon vs. Ohio State picks

The model has simulated Ohio State vs. Oregon 10,000 times and the results are in. The model is leaning Over the total, projecting 58 combined points, and it also says one side of the spread is the better value. You can only see the pick at SportsLine.

So who wins Ohio State vs. Oregon, and which side of the spread is the better value? Visit SportsLine now to see which side of the Oregon vs. Ohio State spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.