Michigan vs. Indiana odds, spread, line: 2023 college football picks ...

The Indiana Hoosiers conclude their two-game Big Ten Conference East Division road swing when they battle the No. 2 Michigan Wolverines on Saturday. The Hoosiers (2-3, 0-2 Big Ten), who are coming off their bye, will be looking to snap Michigan's two-game winning streak in the series since Indiana's 38-21 victory during the 2020 season. The Wolverines (6-0, 3-0 Big Ten), who dominated in a 52-10 win at Minnesota a week ago, have won 31 of their last 34 games. Michigan has also scored 30-plus points in a school-record nine straight games, breaking the previous mark of eight during the 1976 season.

The game will kick off at noon ET from Michigan Stadium in Ann Arbor, Mich. Indiana is averaging 334.2 yards per game, 109th-best in the country, while Michigan averages 414.8, 51st overall. The Wolverines are favored by 33 points in the latest Indiana vs. Michigan odds, while the over-under for total points scored is 45.5. Before making any Michigan vs. Indiana picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of more than $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

Now, the model has set its sights on Michigan vs. Indiana and identified its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for Indiana vs. Michigan:

• Michigan vs. Indiana spread: Michigan -33
• Michigan vs. Indiana over/under: 45.5 points
• IND: The Hoosiers have hit the game total over in seven of their last 11 games
• MICH: The Wolverines have hit the game total under in seven of their last 10 home games
• Michigan vs. Indiana picks: See picks at SportsLine
• Michigan vs. Indiana live stream: fubo (try for free)

Why Michigan can cover

Senior Roman Wilson is the Wolverines' top receiver with 22 receptions for 382 yards (17.4 average) and eight touchdowns. He had three catches for 56 yards (18.7 average) in the win at Minnesota. A week prior at Nebraska, he hauled in four receptions for 58 yards (14.5 average) and a pair of scores. For his career, he has 81 catches for 1,300 yards (16.0 average) and 16 touchdowns, including a long of 75 yards.

On defense, senior defensive back Mike Sainristil is a playmaker. He not only has 13 tackles, including eight solo, but has registered one sack for seven yards, two pass breakups and two interceptions, including one he returned 71 yards for a touchdown. He is in his fourth season with the Wolverines and has registered 77 tackles, including 52 solo, with nine pass breakups and three interceptions. He also has three sacks, including a pair in 2022. See which team to pick here.

Why Indiana can cover

The Hoosiers offense has a number of weapons, including senior wide receiver Cam Camper. Although limited in the loss at Maryland due to injury, he is expected to be healthy and contribute this week. For the season, he has 13 catches and a team-high 249 yards (19.2 average) and one touchdown. That TD came in the four-overtime win over Akron on Sept. 23. In that game, he caught four passes for 103 yards (25.8 average). Over the past two seasons, Camper has 59 receptions for 818 yards (13.9 average) and three touchdowns.

Helping power the defense is senior linebacker Aaron Casey. The fifth-year player leads the team with 43 tackles, including 30 solo. He has registered 10 or more stops in three of the Hoosiers' five games, including 13 against Akron. He had 11 tackles, including nine solo, in a 23-3 season-opening loss to third-ranked Ohio State. Casey has also registered two sacks for 13 yards and one pass breakup in 2023. See which team to pick here.

How to make Indiana vs. Michigan picks

SportsLine's model is leaning Over the point total, predicting a combined 56 points. The model also says one side of the spread hits in well over 50% of simulations. You can see the model's picks at SportsLine. 

So who wins Michigan vs. Indiana, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of more than $2,000 on its top-rated college football spread picks, and find out.