Eli Manning struggled against Peyton Manning and the Colts

Eli Manning, who is expected to announce his retirement after 16 seasons with the New York Giants, didn't have much good fortune against the Indianapolis Colts (0-4) or his brother, Peyton (0-3).

However, he helped pull off a Super Bowl upset at Lucas Oil Stadium, when the Giants beat the New England Patriots. 

This improbable 38-yard pass to Mario Manningham was critical, starting the winning drive. The Giants scored with 1:04 to go in a 21-17 victory. 

Here are Eli Manning's results in that Super Bowl, against Peyton Manning and the Colts.

Feb. 5, 2012 at Lucas Oil Stadium: Giants 21, Patriots 17 

Tom Brady: 27-of-41, 276 yards, 2 touchdowns, 1 interception

Eli: 30-of-40, 296 yards, 1 TD

Against Peyton Manning 

Sept. 10, 2006: Colts 26, Giants 21

Peyton: 25-of-41, 276 yards, 1 touchdown, 1 interception

Eli: 20-of-34, 247 yards, 2 TDs, 1 INT

Sept. 19, 2010: Colts 38 Giants 14 

Peyton: 20-of-26, 255 yards, 3 TDs

Eli: 13-of-24, 161 yards, 2 TDs, 1 INT, sacked 4 times  

Sept. 15, 2013: Broncos 41, Giants 23 

Peyton: 30-of-43, 307 yards, 2 TDs

Eli: 28-of-49, 362 yards, 1 TD, 4 INTs

Also against the Colts 

Nov. 3, 2014: Colts 40, Giants 24 

Andrew Luck: 25-of-46, 354 yards, 4 TDs 

Eli: 27-of-52, 359 yards, 2 TDs, sacked 3 times 

Dec. 23, 2018: Colts 28, Giants 27 

Luck: 31-of-47, 357 yards, 2 TDs, 1 INT

Eli: 25-of-33, 309 yards, 1 TD, 1 INT 

Eli Manning's totals against the Colts: 85-of-143 for 1,076 yards, 7 touchdowns and 3 interceptions. Career totals: 4,895-of-8,119 for 57,023 yards, 366 TDs, 244 INTs. Oddly, the Giants were 118-118 in regular-season games that he started. New York was 8-4 in playoff games he started, winning two Super Bowls (both over the Patriots, the first denying them a 19-0 season). Peyton Manning also won two Super Bowls, one each with the Colts and Broncos.