Steelers vs. Colts odds, line, spread, start time: Week 15 picks ...

Lucas Oil Stadium will host a high-profile matchup between AFC foes on Saturday. Week 15 of the NFL schedule features three games on Saturday, and the Indianapolis Colts will face the Pittsburgh Steelers in the second game on the docket. Pittsburgh and Indianapolis are two of the AFC's six teams with a 7-6 record in 2023. The Steelers are 3-2 on the road and the Colts are 2-4 at home to begin the campaign. 

Kickoff is at 4:30 p.m. ET. For this game, SportsLine consensus lists the Colts as one-point favorites, while the over/under, or total number of points Vegas thinks will be scored, is 42.5 in the latest Steelers vs. Colts odds. Before you make any Colts vs. Steelers picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer simulation model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2023 NFL season on an incredible 176-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 30-21 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Steelers vs. Colts and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Now, here are several NFL odds and betting lines for Steelers vs. Colts:

• Steelers vs. Colts spread: Colts -1
• Steelers vs. Colts over/under: 42.5 points 
• Steelers vs. Colts money line: Colts -120, Steelers +100
• PIT: Steelers are 7-6 against the spread in 2023 
• IND: Colts are 8-5 against the spread in 2023 
• Steelers vs. Colts picks: See picks at SportsLine

Why the Steelers can cover

History is on the side of the Steelers. Pittsburgh has won eight straight games against Indianapolis, now leading the all-time series by a 21-6 margin. The Steelers are also 12-2 in the last 14 games against AFC South opponents, while the Colts are just 2-12 in their last 14 games against AFC North teams. Those two wins for Indianapolis came by only seven combined points, and the Colts are yielding 27.5 points per game in those 14 outings against AFC North foes.

Pittsburgh is elite in ball security, leading the league with only 11 turnovers this season. That includes only three giveaways in the last six games combined. The Steelers also have a cushy matchup against the Colts, with Indianapolis performing at a suboptimal level on defense. The Colts are No. 29 in scoring defense, giving up 25.4 points per game, and opponents have averaged more than 28 points per game at Lucas Oil Stadium this season. Indianapolis is also No. 25 or worse in total yards allowed, first downs allowed, rushing yards allowed, and rushing touchdowns allowed. See which team to pick here.

Why the Colts can cover

Zaire Franklin serves as a centerpiece of a Colts defense that is playing well in key areas this season. Franklin, a 27-year-old linebacker, is leading the NFL with 144 combined tackles and is No. 2 in the league with 86 solo tackles this season. He also has nine games with double-digit tackles in 2023. The Colts are No. 3 in the NFL with 42 sacks, and Indianapolis is also in the top eight with 21 takeaways.

Indianapolis has the NFL's longest streak of creating a takeaway in 18 straight games, and the Colts are in the top five of the league with 13 interceptions and four interceptions for touchdowns. This is also an opportunistic matchup for the Colts against Pittsburgh's underperforming offense. The Steelers have scored 18 points or fewer in four straight games, dipping to only 16.2 points per game this season. Pittsburgh is near the bottom of the league in generating points on only 27.5% of offensive drives, and the Steelers struggle to move the chains on third down, converting only 34.8% of opportunities. See which team to pick here.

How to make Steelers vs. Colts picks

SportsLine's model is leaning Over on the point total, with three players projected for at least 49 rushing yards. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's picks at SportsLine.

So who wins Steelers vs. Colts on Saturday, and which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the Steelers vs. Colts spread you need to jump on Saturday, all from the model that is up well over $7,000 since its inception, and find out.