Arizona Cardinals vs Buffalo Bills live score updates, news, analysis ...

Show Caption

Hide Caption

Damar Hamlin will start for Buffalo Bills in Week 1

Damar Hamlin talks about being named a starter.

The Arizona Cardinals begin their 2024 NFL regular season schedule with an NFL Week 1 game against the Buffalo Bills on Sunday, Sept. 8.

The Cardinals were 4-13 last season. The Bills went 11-6.

Follow our live updates of the game, which is being played at Highmark Stadium in Orchard Park, New York, for the latest score, news, notes, and analysis of the Week 1 NFL game.

DeeJay Dallas returned a kickoff 96 yards to show just how dynamic the new kickoff rules can be. It was the second return of at least 50 yards in the game.

The kickoff came after the Bills took a 31-20 lead on a Josh Allen scramble. Allen appeared to injure his hand on the play.

After Arizona's touchdown, James Conner ran in for a two-point conversion to cut the deficit to three.

Score: Bills 31, Cardinals 28 (8:31 Q4)

Cardinals QB Kyler Murray scrambled for 29 yards — making more than one Bills player miss.

The carry was a part of a drive that saw the Cardinals put the ball in the air just once. In addition to Murray, Greg Dortch and James Conner also had carries.

Conner now has 47 yards on 15 carries. Murray has five carries for 57 yards.

Matt Prater kicked a 31-yard field goal to end the drive, which stalled at the Buffalo 12.

Score: Bills 24, Cardinals 20 (13:32 Q4)

Kyler Murray was sacked for a 5-yard loss and coughed the ball up in the process. Dorian Williams recovered the ball at the Arizona 21 for the Bills.

Five short plays later, the Bills found the endzone on an 11-yard run by Khalil Shakir.

Buffalo has now scored 21 unanswered points after trailing the Cardinals 17-3. It's the first time the Cardinals have trailed in the game.

Score: Buffalo 24, Cardinals 17.

Matt Hollins caught an 11-yard pass from Josh Allen to help the Bills draw even with the Cardinals early in the second half.

The Bills received the opening kickoff in the second half. A penalty for the kickoff bouncing short of the landing zone, resulted in a penalty that gave the Bills possession on their own 40.

From there, it took 10 plays for Buffalo to get into the endzone.

Allen is 10-for-11 passing for 134 yards and a touchdown. Hollins has two catches for 25 yards.

The Cardinals led 17-3 late in the first half.

Score: Bills 17, Cardinals 17 (9:51 Q2)

Kyler Murray was 16-for-19 passing for 131 yards and a touchdown and the Arizona Cardinals led the Bills 20-17 at the half.

Bills QB Josh Allen scrambled for a touchdown in the final seconds of the first half to pull the Bills within a score. Buffalo will get the back to start the second half.

Allen is 5-for-5 passing for 76 yards. He has three carries for 20 yards. He has been sacked twice and lost a fumble.

Murray leads the Cardinals with 29 rushing yards on three carries. James Cook leads Buffalo with 49 yards on eight carries.

Score: Cardinals 17, Bills 10 (halftime)

Cardinals running back James Conner was the workhorse on the team's first drive, but the ball went to Michael Wilson for the touchdown.

Late in the second quarter, the Cardinals were chipping down the field with Trey Benson at running back. The rookie had three carries for 19 yards. But when it came time to punch it into the end zone, it was Conner time.

Conner entered to carry the ball 3 yards for a touchdown. Matt Prater added the point after for a 17-3 lead.

Score: Cardinals 17, Bills 3 (2:40 Q2)

The first pass thrown to Cardinals rookie WR Marvin Harrison Jr. bounced off the receiver's hands.

The Cardinals went right back to Harrison on the next play for a gain of 4 yards.

A touchdown by Bills QB Josh Allen was negated by an offensive face mask penalty. The Bills were forced to settle for a 37-yard field goal.

It was the second disappointing drive for the home team, which fumbled away the first possession.

The Cardinals have outgained the Bills 120-76 and dominated the time of possession.

Allen is 2-for-2 passing for 37 yards. James Cook has 49 yards on eight carries.

Cardinals QB Kyler Murray is 10-for-11 with 87 yards and a touchdown. He leads the team in rushing with two carries for 17 yards.

Score: Cardinals 10, Bills 3 (9:47 Q2)

Bills quarterback Josh Allen fumbled on a sack. That ball was recovered by Justin Jones for the Cardinals.

The Cardinals worked their way down to the Buffalo 12 before the drive stalled.

Arizona was able to net a 29-yard field goal from Matt Prater off that bonus possession.

Score: Cardinals 10, Bills 0 (14:57 Q2)

Matt Prater bounced a kickoff down to the Buffalo 2-yard line where the Bills Brandon Codrington scooped it up. He returned the ball 53 yards.

The Bills began their first offensive series at the Arizona 45.

Kyler Murray completed a 5-yard pass to Michael Wilson for the Cardinals first TD of the young season. Matt Prater's point after was good for a 7-0 lead.

The drive covered 70 yards with 13 plays.

Murray was 4-for-5 for 44 yards on the drive. Marvin Harrison Jr was targetted once along the sideline but didn't have a catch.

The drive was extended on a third down play that saw Murray scramble 6 yards before sliding. The Bills were flagged for unnecessary roughness, which gave the Cardinals 10 more yards and a first down.

Score: Cardinals 7, Bills 0 (7:47 Q1)

Running back James Conner had the first five touches for the Arizona Cardinals with three carries and two catches. After Kyler Murray completed an 8-yard pass to Greg Dortch, the ball again went to Conner.

In the first 4 minutes of the game, Conner has accounted for 40 yards.

Score: Cardinals 0, Bills 0 (10:37 Q1)

Cardinals vs Bills schedule: What time is NFL Week 1 game?

The game is on Sunday, Sept. 8 at 10 a.m. MST, 1 p.m. ET.

Who wins NFL Week 1 game? Arizona Cardinals vs Buffalo Bills picks, predictions, odds

Cardinals vs Bills venue: Where is NFL Week 1 game?

The game is being played at Highmark Stadium in Orchard Park, New York.

Cardinals vs Bills TV: What channel is NFL Week 1 game on?

The game can be seen on CBS.

NFL Week 1 schedule: Television channels, how to watch, stream games

Cardinals vs Bills streaming: How do I watch NFL Week 1 game on livestream?

Streaming options for the game include Paramount+, CBS's subscription streaming service, and FUBO, which offers a free trial.

Cardinals vs Bills announcers: Who is calling the NFL Week 1 game?

Tom McCarthy (play-by-play), Ross Tucker (analyst) and Jay Feely (analyst) are scheduled to be the announcers for the Cardinals at Bills Week 1 NFL game.

NFL Week 1 announcers: Television broadcasters, announcing crews for Week 1 NFL schedule

Cardinals vs Bills game odds: Who is favored in NFL Week 1?

The Bills are a 6-point favorite over the Cardinals in the game, according to NFL Week 1 odds provided by BetMGM Sportsbook.

Buffalo is -275 on the moneyline, while Arizona is +220.

The over/under (point total) is set at 48 points.

NFL Week 1 odds: Point spreads, moneylines, over/unders for betting on games

Pregame reading for Arizona Cardinals vs Buffalo Bills

Arizona Cardinals depth chart: How roster stacks up for NFL Week 1 game vs Buffalo Bills

Nike releases Arizona Cardinals running shoe to celebrate start of NFL season

Arizona Cardinals at Buffalo Bills: Damar Hamlin gets 1st start since cardiac arrest

NFL power rankings Week 1: Who can challenge Kansas City Chiefs in 2024-25 season?

Super Bowl odds 2025 for NFL Super Bowl LIX betting: Chiefs, 49ers Super Bowl 59 favorites

Arizona Cardinals name Kyler Murray among four captains as opener nears

NFL MVP odds 2024-2025: Betting futures have Patrick Mahomes, Josh Allen award favorites

How to buy Arizona Cardinals tickets? See prices for games on 2024 schedule

Arizona Cardinals schedule 2024: Everything to know after NFL's official reveal

We occasionally recommend interesting products and services. If you make a purchase by clicking one of the links, we may earn an affiliate fee. USA TODAY Network newsrooms operate independently, and this doesn’t influence our coverage.