Oregon vs. Michigan State prediction, odds, spread, line: 2024 ...

The Friday slate of the Week 6 college football schedule is highlighted by a Big Ten showdown between the No. 6 Oregon Ducks (4-0, 1-0) and the Michigan State Spartans (3-2, 1-1) at Autzen Stadium. The Ducks survived early season scares from Idaho and Boise State before notching blowout wins over Oregon State and UCLA in their last two games. Quarterback Dillon Gabriel and running back Jordan James have excelled for head coach Dan Lanning in the first month of the season. The Spartans were blown out by Ohio State in their last outing, losing 38-7. Michigan State is 2-0 against the spread in road games this season. 

Kickoff in Eugene is scheduled for 9 p.m. ET. The Ducks are favored by 23.5 points in the latest Michigan State vs. Oregon odds via SportsLine consensus, while the over/under is 52 points. Before making any Oregon vs. Michigan State picks, you need to see the Week 6 college football predictions and betting advice from SportsLine's Jimmie Kaylor. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season way up.

Now, Kaylor has dialed in on Oregon vs. Michigan State on Friday and just revealed his picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and betting lines on the spread, money line and over/under for Michigan State vs. Oregon:

• Oregon vs. Michigan State spread: Oregon -23.5
• Oregon vs. Michigan State over/under: 52 points 
• Oregon vs. Michigan State money line: Oregon -2381, Michigan State +1104
• Oregon vs. Michigan State picks: See picks at SportsLine
• Oregon vs. Michigan State streaming: FuboTV (Try for free)

Why Oregon can cover

From a talent perspective alone, Oregon has a massive advantage in this matchup. Outside of a disappointing effort against Boise State, the Ducks have been outstanding on the defensive side of the ball. They enter this matchup allowing 266.8 total yards per game (154.8 passing, 112.0 rushing) and 18.8 points per game this season. The Ducks have one of the best pass rush units in college football, led by defensive linemen Matayo Uiagalelei (3.0 sacks), Jordan Burch (2.5 sacks), and Derrick Harmon (2.0 sacks).

Offensively, Gabriel gets a lot of the attention, but he has an outstanding supporting cast. Offensive tackles Josh Conerly Jr. and Ajani Cornelius are both likely future early NFL Draft picks, and the Ducks receiving corps (Tez Johnson, Evan Stewart, Traeshon Holden, and Terrance Ferguson) are among the best in the Big Ten. James has proven to be a home run threat, with 386 yards and four touchdowns on 64 carries this season. See which team to pick here. 

Why Michigan State can cover

First-year Michigan State head coach Jonathan Smith is no stranger to the Ducks. Prior to landing the MSU job, Smith had served as the head coach at Oregon State for the last six seasons. During his time in Corvallis, Smith led the Beavers to a 2-4 record against Oregon, despite being sizable underdogs in each of those games. 

Michigan State quarterback Aidan Chiles followed Smith from Corvallis to East Lansing during the offseason. Chiles has been inconsistent to open the season, but his overall talent is undeniable. The sophomore quarterback was a four-star, national top-100 recruit coming out of high school, according to 247Sports. His running ability could present a significant problem for Oregon's defense. See which team to pick here. 

How to make Michigan State vs. Oregon picks

Kaylor has analyzed Oregon vs. Michigan State from every angle and he's leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

So who wins Michigan State vs. Oregon on Friday, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $5,790 for $100 college football bettors in 2023, and find out.