Clemson vs. Wake Forest odds, spread, line: 2024 college football ...

The No. 10 Clemson Tigers (4-1) will try to stay on track for a College Football Playoff spot when they face the Wake Forest Demon Deacons (2-3) on Saturday afternoon. Clemson opened the season with a blowout loss at then-No. 1 Georgia, but it has responded with a four-game winning streak. The Tigers have won all four of those games by more than two touchdowns, including a 29-13 win at Florida State last week. Wake Forest snapped its three-game losing streak with a 34-30 win at NC State, which was its first road game of the season.

Kickoff is set for noon ET at Allegacy Federal Credit Union Stadium in Winston-Salem. After opening at -17.5, the Tigers are now 21-point favorites, per SportsLine consensus, in the latest Wake Forest vs. Clemson odds. The over/under for total points is 62.5. Before entering any Clemson vs. Wake Forest picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks since inception, and is 8-4 on top-rated picks over the past two weeks of this season. Anyone who has followed it has seen strong returns.

The model has set its sights on Clemson vs. Wake Forest. You can head to SportsLine to see its picks. Here are several college football betting lines for the spread, money line and over/under:

• Wake Forest vs. Clemson spread: Clemson -21
• Wake Forest vs. Clemson over/under: 62.5 points
• Wake Forest vs. Clemson money line: Clemson -1613, Wake Forest +881
• Wake Forest vs. Clemson picks: See picks here
• Wake Forest vs. Clemson streaming: FuboTV (Try for free)

Why Wake Forest can cover

Wake Forest gave Clemson trouble on the road last year, easily covering the spread as a 21-point underdog in a 17-12 final. The Demon Deacons held Clemson to just 131 total passing yards and forced two turnovers in that game. They are coming off their best performance of the season, taking down NC State as 5-point road underdogs to snap a three-game losing streak. 

Junior running back Demond Claiborne rushed 20 times for 136 yards and two touchdowns, averaging 6.8 yards per carry. He also caught a touchdown pass from senior quarterback Hank Bachmeier, who threw two passing touchdowns. Wake Forest has covered the spread in eight of its last 11 games in the month of October. See which team to pick here. 

Why Clemson can cover

Clemson has looked much improved since its season-opening loss to Georgia, scoring an average of 48.5 points during its four-game winning streak. The Tigers are averaging 465.6 yards per game and 6.1 yards per rushing attempt, led by running back Phil Mafah, who has 496 rushing yards and 7.3 yards per carry. Quarterback Cade Klubnik is a dual-threat star, passing for 1,219 yards and 14 touchdowns while rushing for 168 yards.

They are facing a Wake Forest defense that is giving up 460.2 yards per game and ranks outside the top 100 nationally in most key defensive categories. The Demon Deacons are allowing 31 points per game, with all of their FBS opponents scoring at least 30 points. Clemson has won 15 straight meetings between these teams and has covered the spread in seven of its last 10 games dating back to last season. See which team to pick here. 

How to make Wake Forest vs. Clemson picks

The model has simulated Clemson vs. Wake Forest 10,000 times and the results are in. The model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Wake Forest vs. Clemson, and which side of the spread is hitting well over 50% of the time? Visit SportsLine now to see which side of the Clemson vs. Wake Forest spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.